TG/DTA Analysis: Evaluating Decomposition Temperature in Pharmaceuticals

Thermal analysis plays a crucial role in the pharmaceutical industry, serving applications that range from research and development to pharmaceutical quality control. Pharmaceuticals are composed of complex organic and inorganic materials, and their thermal behavior must be well understood to ensure product stability and effectiveness.

One of the primary thermoanalytical methods used in pharmaceutical studies is thermogravimetric analysis (TGA), facilitated by Hitachi’s NEXTA STA200. This helps determine thermal stability, decomposition temperature, and moisture content analysis of various compounds. By employing thermogravimetric measurement, researchers can evaluate the thermal properties of materials and gain insights into their stability. This is particularly important in the study of digestive medicine, where thermal behavior can impact the efficacy and safety of digestive problems medicine formulations.

Hitachi NEXTA STA200

Measurements and Results

A TG/DTA analysis was conducted on four types of digestive medicine (labeled A~D) to assess their thermal behavior. The samples, each weighing 15mg, were heated in an air environment at a rate of 20°C/min.

Key Observations:

This indicates shared components, whereas unique decomposition points suggest differences in formulation.

Figure 2: DTA, TG and DTG Curves for Four Types of Digestive Medicine

Importance of Thermoanalytical Methods in Pharmaceuticals

Thermal analysis techniques such as thermogravimetry, differential thermal analysis provide valuable insights into drug composition and behavior under thermal stress. This is essential for pharmaceutical quality control, ensuring that medications maintain their effectiveness and stability throughout their shelf life.

For digestive medicine, such studies help in identifying active ingredients and excipients that may degrade at certain temperature ranges, allowing manufacturers to optimize formulations accordingly. By analyzing thermal properties of materials, pharmaceutical scientists can improve product stability and enhance therapeutic outcomes.

Conclusion

The application of thermogravimetric measurement and differential thermal analysis in the pharmaceutical industry is vital for maintaining the integrity and effectiveness of drugs. Through TG/DTA analysis, using advanced instruments like Hitachi NEXTA STA200, researchers can evaluate thermal stability, determine decomposition temperatures, and perform moisture content analysis, ensuring that medications, particularly those used in digestive problems medicine, meet stringent quality standards. The use of advanced thermoanalytical methods will continue to enhance pharmaceutical formulations and ensure safe and effective treatments for consumers.

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